Quick map
Bookmark-friendly1) The endocannabinoid system (ECS)
The ECS is a body-wide communication network. Your body makes its own “cannabinoid-like” messengers (endocannabinoids). These messengers bind to receptors, and enzymes break them down when the message is done.
Examples: anandamide and 2‑AG (your body produces them).
CB1 and CB2 are the best-known, but they aren’t the only players.
They break down endocannabinoids after the signal is delivered.
Think of the ECS as a “balance” system. Cannabis compounds can amplify, reduce, or redirect ECS signaling.
2) CB1 vs CB2 receptors
More brain + nervous system
CB1 is heavily expressed in the brain. THC strongly activates CB1, which is why it can change perception, attention, coordination, time sense, and short-term memory.
More immune + peripheral tissues
CB2 is more common outside the brain, especially in immune-related tissues. CB2 signaling is often discussed in inflammation/immune modulation conversations.
Cannabis effects can involve many systems beyond CB1/CB2, including serotonin signaling and other pathways.
3) THC: why it feels “high”
THC is the main intoxicating cannabinoid. It changes neurotransmitter release through CB1 activity, which can shift mood, perception, and body sensation.
Also: laughter, music enhancement, “body melt.”
Also: fast heart rate, dizziness, “too high.”
Sleep, food, stress, and environment matter a lot.
4) CBD: what it can (and can’t) do
CBD is non-intoxicating and interacts with the body differently than THC. It has weak direct activity at CB1/CB2, and may influence multiple signaling systems. For some people, CBD can reduce the intensity of THC.
Reality check
- CBD is not a cure-all. Effects depend on dose, product, and the person.
- CBD can interact with medications (especially those processed by liver enzymes). Ask a clinician if unsure.
- COAs matter: “CBD” products can be mislabeled.
5) Terpenes + flavor
Terpenes are aroma compounds found throughout the plant world. They drive smell and taste, and may influence the character of the experience — but terpene science is still developing.
Often described as bright/uplifting.
Often described as heavy/relaxing.
Often described as crisp/clear.
Unique: can interact with CB2.
6) How you consume changes everything
Inhaled cannabis hits quickly because cannabinoids enter the bloodstream through the lungs. Edibles take longer because they must be digested and processed by the liver.
Inhaled (vape/smoke)
- Fast onset (minutes)
- Easier to titrate (stop when you feel good)
- Shorter duration (often 1–3 hours)
Edibles
- Slow onset (often 30–120 minutes)
- Harder to dose (people redose too soon)
- Longer duration (often 4–8+ hours)
Tinctures: under the tongue vs swallowed
Tinctures are liquid cannabis extracts (commonly in MCT oil, hemp seed oil, glycerin, or alcohol). The key detail is how you take it: holding it under your tongue can feel faster than swallowing it like an edible.
Sublingual (under the tongue)
- Onset: often ~15–45 minutes
- Peak: ~1–2 hours
- Duration: often ~3–6 hours
- How: place drops under the tongue, hold 30–90 seconds, then swallow
Some cannabinoids can be absorbed through tissues in the mouth, which is why this can feel quicker than edibles.
Swallowed (like an edible)
- Onset: often ~45–120 minutes
- Peak: ~2–4 hours
- Duration: often ~4–8+ hours
- How: swallow directly or mix into food/drink
This route is processed through digestion and the liver, so timing is slower and re-dosing too soon is the most common mistake.
Begin with a small amount and wait long enough to feel the full effect.
Some formulas separate—shaking helps keep dosing more consistent.
CBD/THC can interact with medications. If you take prescriptions, ask a clinician or pharmacist.
Educational content only. Not medical advice. Do not drive after THC use. Keep out of reach of children and pets.
7) Onset & duration (rule-of-thumb)
| Method | Onset | Peak | Total duration |
|---|---|---|---|
| Inhaled | 1–10 min | 15–30 min | 1–3 hrs |
| Edibles | 30–120 min | 2–4 hrs | 4–8+ hrs |
| Tincture (sublingual) | 15–45 min | 1–2 hrs | 3–6 hrs |
| Tincture (swallowed) | 45–120 min | 2–4 hrs | 4–8+ hrs |
These are general ranges. Food, metabolism, formulation, and tolerance can shift timing — especially with edibles and swallowed tinctures.
8) Dosing basics (edibles)
Safest approach: start low and go slow. If you’re new, start with a low dose and wait long enough before taking more.
Often a gentle intro for sensitive users.
Typical “standard” range for many.
Before deciding to redose (edibles).
If you feel “too high”: hydrate, breathe slowly, find a calm environment, and wait it out. If severe symptoms occur, seek medical help.
9) Safer use + interactions
Safer-use basics
- Don’t drive or operate machinery after using THC.
- Keep products locked away from kids/pets.
- Avoid mixing THC with alcohol if you’re new.
- If you’re anxiety-prone, start lower and choose calmer settings.
Medication interactions
THC and CBD can interact with medications. CBD especially can affect how some drugs are metabolized. If you take prescription meds, ask a clinician or pharmacist before combining.
Know the warning signs
If someone has chest pain, fainting, severe confusion, or persistent vomiting, treat it as medical — call for help.
Notice: This website does not offer cannabis for sale. Products are sold only through licensed dispensaries. For required warnings and compliance language, visit the Compliance page.